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Activation of Benznidazole by Trypanosomal Type I Nitroreductases Results in Glyoxal Formation

Benznidazole, a 2-nitroimidazole, is the front-line treatment used against American trypanosomiasis, a parasitic infection caused by Trypanosoma cruzi. Despite nearly 40 years of use, the trypanocidal activity of this prodrug is not fully understood. It has been proposed that benznidazole activation...

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Autors principals: Hall, Belinda S., Wilkinson, Shane R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256028/
https://ncbi.nlm.nih.gov/pubmed/22037852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05135-11
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