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The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase

Humans lack the ability to synthesize vitamin C (ascorbate) due to the absence of gulonolactone oxidase, the last enzyme in the biosynthetic pathway in most other mammals. The corresponding oxidoreductase in trypanosomes therefore represents a target that may be therapeutically exploitable. This is...

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Detalhes bibliográficos
Main Authors: Logan, Flora J., Taylor, Martin C., Wilkinson, Shane R., Kaur, Harparkash, Kelly, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275072/
https://ncbi.nlm.nih.gov/pubmed/17627608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070766
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