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MECHANISMS OF RESISTANCE TO ANTIPARASITIC DRUGS IN TRYPANOSOMA CRUZI. CORRELATIONS BETWEEN GENOTYPE AND RESISTANCE
The nitroheterocyclic compounds benznidazole and nifurtimox are the only drugs licensed for treatment of Trypanosoma cruzi infections. Both are prodrugs and do not have significant trypanocidal properties until they have undergone intra-parasitic activation. The enzyme responsible is a nitroreductas...
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Publicado no: | Revista Española de Salud Pública |
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Main Authors: | , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Ministerio de Sanidad
2013
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Assuntos: | |
Acesso em linha: | https://www.redalyc.org/articulo.oa?id=17027695003 |
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