Insights Into Metabolic Mechanisms and Their Application in the Treatment of NASH

per White, Phillip J., Abdelmalek, Manal F.
Publicat a Clin Liver Dis (Hoboken) (2021)

Transgenic Restoration of Long-Chain n-3 Fatty Acids in Insulin Target Tissues Improves Resolution Capacity and Alleviates Obesity-Linked Inflammation and Insulin Resistance in Hig...

per White, Phillip J., Arita, Makoto, Taguchi, Ryo, Kang, Jing X., Marette, André
Publicat 2010

Endotoxin Mediated-iNOS Induction Causes Insulin Resistance via ONOO(−) Induced Tyrosine Nitration of IRS-1 in Skeletal Muscle

per Pilon, Geneviève, Charbonneau, Alexandre, White, Phillip J., Dallaire, Patrice, Perreault, Mylène, Kapur, Sonia, Marette, André
Publicat 2010

Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis

per White, Phillip J., St-Pierre, Philippe, Charbonneau, Alexandre, Mitchell, Patricia, St-Amand, Emmanuelle, Marcotte, Bruno, Marette, André
Publicat a Nat Med (2014)

Focused Ultrasound Platform for Investigating Therapeutic Neuromodulation Across the Human Hippocampus

per Brinker, Spencer T, Preiswerk, Frank, White, Phillip J, Mariano, Timothy Y, McDannold, Nathan J, Bubrick, Ellen J
Publicat a Ultrasound Med Biol (2020)

Lowering circulating apolipoprotein E levels improves aged bone fracture healing

per Huang, Rong, Zong, Xiaohua, Nadesan, Puviindran, Huebner, Janet L., Kraus, Virginia B., White, James P., White, Phillip J., Baht, Gurpreet S.
Publicat a JCI Insight (2019)

BCAA Supplementation in Mice with Diet-induced Obesity Alters the Metabolome Without Impairing Glucose Homeostasis

per Lee, Jennifer, Vijayakumar, Archana, White, Phillip J, Xu, Yuping, Ilkayeva, Olga, Lynch, Christopher J, Newgard, Christopher B, Kahn, Barbara B
Publicat a Endocrinology (2021)

Dietary branched-chain amino acid restriction alters fuel selection and reduces triglyceride stores in hearts of Zucker fatty rats

per McGarrah, Robert W., Zhang, Guo-Fang, Christopher, Bridgette A., Deleye, Yann, Walejko, Jacquelyn M., Page, Stephani, Ilkayeva, Olga, White, Phillip J., Newgard, Christopher B.
Publicat a Am J Physiol Endocrinol Metab (2020)

Impact of lifestyle Intervention on branched‐chain amino acid catabolism and insulin sensitivity in adolescents with obesity

per Jachthuber Trub, Catherine, Balikcioglu, Metin, Freemark, Michael, Bain, James, Muehlbauer, Michael, Ilkayeva, Olga, White, Phillip J., Armstrong, Sarah, Østbye, Truls, Grambow, Steven, Gumus Balikcioglu, Pinar
Publicat a Endocrinol Diabetes Metab (2021)

MiR-29 Regulates de novo Lipogenesis in the Liver and Circulating Triglyceride Levels in a Sirt1-Dependent Manner

per Hung, Yu-Han, Kanke, Matt, Kurtz, Catherine Lisa, Cubitt, Rebecca L., Bunaciu, Rodica P., Zhou, Liye, White, Phillip J., Vickers, Kasey C., Hussain, Mohammed Mahmood, Li, Xiaoling, Sethupathy, Praveen
Publicat a Front Physiol (2019)

High Resolution Melt (HRM) analysis is an efficient tool to genotype EMS mutants in complex crop genomes

per Lochlainn, Seosamh Ó, Amoah, Stephen, Graham, Neil S, Alamer, Khalid, Rios, Juan J, Kurup, Smita, Stoute, Andrew, Hammond, John P, Østergaard, Lars, King, Graham J, White, Phillip J, Broadley, Martin R
Publicat 2011

Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever

per Yoneshiro, Takeshi, Kataoka, Naoya, Walejko, Jacquelyn M, Ikeda, Kenji, Brown, Zachary, Yoneshiro, Momoko, Crown, Scott B, Osawa, Tsuyoshi, Sakai, Juro, McGarrah, Robert W, White, Phillip J, Nakamura, Kazuhiro, Kajimura, Shingo
Publicat a eLife (2021)

Acute suppression of insulin resistance-associated hepatic miR-29 in vivo improves glycemic control in adult mice

per Hung, Yu-Han, Kanke, Matt, Kurtz, C. Lisa, Cubitt, Rebecca, Bunaciu, Rodica P., Miao, Ji, Zhou, Liye, Graham, James L., Hussain, M. Mahmood, Havel, Peter, Biddinger, Sudha, White, Phillip J., Sethupathy, Praveen
Publicat a Physiol Genomics (2019)

Loss of BCAA catabolism during carcinogenesis enhances mTORCl activity and promotes tumor development and progression

per Ericksen, Russell E., Lim, Siew Lan, McDonnell, Eoin, Shuen, Wai Ho, Vadiveloo, Maya, White, Phillip J., Ding, Zhaobing, Kwok, Royston, Lee, Philip, Radda, George K., Toh, Han Chong, Hirschey, Matthew D., Han, Weiping
Publicat a Cell Metab (2019)

Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice

per Choi, Béatrice S.-Y., Daniel, Noëmie, Houde, Vanessa P., Ouellette, Adia, Marcotte, Bruno, Varin, Thibault V., Vors, Cécile, Feutry, Perrine, Ilkayeva, Olga, Ståhlman, Marcus, St-Pierre, Philippe, Bäckhed, Fredrik, Tremblay, Angelo, White, Phillip J., Marette, André
Publicat a Nat Commun (2021)

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

per White, Phillip J., Lapworth, Amanda L., An, Jie, Wang, Liping, McGarrah, Robert W., Stevens, Robert D., Ilkayeva, Olga, George, Tabitha, Muehlbauer, Michael J., Bain, James R., Trimmer, Jeff K., Brosnan, M. Julia, Rolph, Timothy P., Newgard, Christopher B.
Publicat a Mol Metab (2016)

Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism

per Shin, Andrew C., Fasshauer, Martin, Filatova, Nika, Grundell, Linus A., Zielinski, Elizabeth, Zhou, Jian-Ying, Scherer, Thomas, Lindtner, Claudia, White, Phillip J., Lapworth, Amanda L., Ilkayeva, Olga, Knippschild, Uwe, Wolf, Anna M., Scheja, Ludger, Grove, Kevin L., Smith, Richard D., Qian, Wei-Jun, Lynch, Christopher J., Newgard, Christopher B., Buettner, Christoph
Publicat a Cell Metab (2014)

The BCKDH kinase and phosphatase integrate BCAA and lipid metabolism via regulation of ATP-citrate lyase

per White, Phillip J., McGarrah, Robert W., Grimsrud, Paul A., Tso, Shih-Chia, Yang, Wen-Hsuan, Haldeman, Jonathan, Grenier-Larouche, Thomas, An, Jie, Lapworth, Amanda L, Astapova, Inna, Hannou, Sarah A., George, Tabitha, Arlotto, Michelle, Olson, Lyra B., Lai, Michelle, Zhang, Guofang, Ilkayeva, Olga, Herman, Mark A., Wynn, R. Max, Chuang, David T., Newgard, Christopher B.
Publicat a Cell Metab (2018)

Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans

per Glynn, Erin L., Piner, Lucy W., Huffman, Kim M., Slentz, Cris A., Elliot-Penry, Lorraine, AbouAssi, Hiba, White, Phillip J., Bain, James R., Muehlbauer, Michael J., Ilkayeva, Olga R., Stevens, Robert D., Porter Starr, Kathryn N., Bales, Connie W., Volpi, Elena, Brosnan, M. Julia, Trimmer, Jeff K., Rolph, Timothy P., Newgard, Christopher B., Kraus, William E.
Publicat a Diabetologia (2015)

Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart

per Walejko, Jacquelyn M., Christopher, Bridgette A., Crown, Scott B., Zhang, Guo-Fang, Pickar-Oliver, Adrian, Yoneshiro, Takeshi, Foster, Matthew W., Page, Stephani, van Vliet, Stephan, Ilkayeva, Olga, Muehlbauer, Michael J., Carson, Matthew W., Brozinick, Joseph T., Hammond, Craig D., Gimeno, Ruth E., Moseley, M. Arthur, Kajimura, Shingo, Gersbach, Charles A., Newgard, Christopher B., White, Phillip J., McGarrah, Robert W.
Publicat a Nat Commun (2021)