The BCKDH kinase and phosphatase integrate BCAA and lipid metabolism via regulation of ATP-citrate lyase

Branched chain amino acids (BCAA) are strongly associated with dysregulated glucose and lipid metabolism, but the underlying mechanisms are poorly understood. We report that inhibition of the kinase (BDK) or overexpression of the phosphatase (PPM1K) that regulate branched-chain ketoacid dehydrogenas...

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Vydáno v:Cell Metab
Hlavní autoři: White, Phillip J., McGarrah, Robert W., Grimsrud, Paul A., Tso, Shih-Chia, Yang, Wen-Hsuan, Haldeman, Jonathan, Grenier-Larouche, Thomas, An, Jie, Lapworth, Amanda L, Astapova, Inna, Hannou, Sarah A., George, Tabitha, Arlotto, Michelle, Olson, Lyra B., Lai, Michelle, Zhang, Guofang, Ilkayeva, Olga, Herman, Mark A., Wynn, R. Max, Chuang, David T., Newgard, Christopher B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5990471/
https://ncbi.nlm.nih.gov/pubmed/29779826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.04.015
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