The BCKDH kinase and phosphatase integrate BCAA and lipid metabolism via regulation of ATP-citrate lyase

Branched chain amino acids (BCAA) are strongly associated with dysregulated glucose and lipid metabolism, but the underlying mechanisms are poorly understood. We report that inhibition of the kinase (BDK) or overexpression of the phosphatase (PPM1K) that regulate branched-chain ketoacid dehydrogenas...

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Bibliografski detalji
Izdano u:Cell Metab
Glavni autori: White, Phillip J., McGarrah, Robert W., Grimsrud, Paul A., Tso, Shih-Chia, Yang, Wen-Hsuan, Haldeman, Jonathan, Grenier-Larouche, Thomas, An, Jie, Lapworth, Amanda L, Astapova, Inna, Hannou, Sarah A., George, Tabitha, Arlotto, Michelle, Olson, Lyra B., Lai, Michelle, Zhang, Guofang, Ilkayeva, Olga, Herman, Mark A., Wynn, R. Max, Chuang, David T., Newgard, Christopher B.
Format: Artigo
Jezik:Inglês
Izdano: 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5990471/
https://ncbi.nlm.nih.gov/pubmed/29779826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.04.015
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