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The BCKDH kinase and phosphatase integrate BCAA and lipid metabolism via regulation of ATP-citrate lyase

Branched chain amino acids (BCAA) are strongly associated with dysregulated glucose and lipid metabolism, but the underlying mechanisms are poorly understood. We report that inhibition of the kinase (BDK) or overexpression of the phosphatase (PPM1K) that regulate branched-chain ketoacid dehydrogenas...

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מידע ביבליוגרפי
הוצא לאור ב:	Cell Metab
Main Authors:	White, Phillip J., McGarrah, Robert W., Grimsrud, Paul A., Tso, Shih-Chia, Yang, Wen-Hsuan, Haldeman, Jonathan, Grenier-Larouche, Thomas, An, Jie, Lapworth, Amanda L, Astapova, Inna, Hannou, Sarah A., George, Tabitha, Arlotto, Michelle, Olson, Lyra B., Lai, Michelle, Zhang, Guofang, Ilkayeva, Olga, Herman, Mark A., Wynn, R. Max, Chuang, David T., Newgard, Christopher B.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2018
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5990471/ https://ncbi.nlm.nih.gov/pubmed/29779826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.04.015
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The BCKDH kinase and phosphatase integrate BCAA and lipid metabolism via regulation of ATP-citrate lyase

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