Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism

Circulating branched-chain amino acid (BCAA) levels are elevated in obesity/diabetes and are a sensitive predictor for type 2 diabetes. Here we show in rats that insulin dose-dependently lowers plasma BCAA levels through induction of hepatic protein expression and activity of branched-chain α keto-a...

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Publicado no:Cell Metab
Main Authors: Shin, Andrew C., Fasshauer, Martin, Filatova, Nika, Grundell, Linus A., Zielinski, Elizabeth, Zhou, Jian-Ying, Scherer, Thomas, Lindtner, Claudia, White, Phillip J., Lapworth, Amanda L., Ilkayeva, Olga, Knippschild, Uwe, Wolf, Anna M., Scheja, Ludger, Grove, Kevin L., Smith, Richard D., Qian, Wei-Jun, Lynch, Christopher J., Newgard, Christopher B., Buettner, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254305/
https://ncbi.nlm.nih.gov/pubmed/25307860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.09.003
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