Endotoxin Mediated-iNOS Induction Causes Insulin Resistance via ONOO(−) Induced Tyrosine Nitration of IRS-1 in Skeletal Muscle

BACKGROUND: It is believed that the endotoxin lipopolysaccharide (LPS) is implicated in the metabolic perturbations associated with both sepsis and obesity (metabolic endotoxemia). Here we examined the role of inducible nitric oxide synthase (iNOS) in skeletal muscle insulin resistance using LPS cha...

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Bibliografische gegevens
Hoofdauteurs: Pilon, Geneviève, Charbonneau, Alexandre, White, Phillip J., Dallaire, Patrice, Perreault, Mylène, Kapur, Sonia, Marette, André
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2010
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3011021/
https://ncbi.nlm.nih.gov/pubmed/21206533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015912
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