Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart

Branched-chain amino acids (BCAA) and their cognate α-ketoacids (BCKA) are elevated in an array of cardiometabolic diseases. Here we demonstrate that the major metabolic fate of uniformly-(13)C-labeled α-ketoisovalerate ([U-(13)C]KIV) in the heart is reamination to valine. Activation of cardiac bran...

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Publicado no:Nat Commun
Main Authors: Walejko, Jacquelyn M., Christopher, Bridgette A., Crown, Scott B., Zhang, Guo-Fang, Pickar-Oliver, Adrian, Yoneshiro, Takeshi, Foster, Matthew W., Page, Stephani, van Vliet, Stephan, Ilkayeva, Olga, Muehlbauer, Michael J., Carson, Matthew W., Brozinick, Joseph T., Hammond, Craig D., Gimeno, Ruth E., Moseley, M. Arthur, Kajimura, Shingo, Gersbach, Charles A., Newgard, Christopher B., White, Phillip J., McGarrah, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7960706/
https://ncbi.nlm.nih.gov/pubmed/33723250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21962-2
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