Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart

Branched-chain amino acids (BCAA) and their cognate α-ketoacids (BCKA) are elevated in an array of cardiometabolic diseases. Here we demonstrate that the major metabolic fate of uniformly-(13)C-labeled α-ketoisovalerate ([U-(13)C]KIV) in the heart is reamination to valine. Activation of cardiac bran...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Walejko, Jacquelyn M., Christopher, Bridgette A., Crown, Scott B., Zhang, Guo-Fang, Pickar-Oliver, Adrian, Yoneshiro, Takeshi, Foster, Matthew W., Page, Stephani, van Vliet, Stephan, Ilkayeva, Olga, Muehlbauer, Michael J., Carson, Matthew W., Brozinick, Joseph T., Hammond, Craig D., Gimeno, Ruth E., Moseley, M. Arthur, Kajimura, Shingo, Gersbach, Charles A., Newgard, Christopher B., White, Phillip J., McGarrah, Robert W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7960706/
https://ncbi.nlm.nih.gov/pubmed/33723250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21962-2
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