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Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart
Branched-chain amino acids (BCAA) and their cognate α-ketoacids (BCKA) are elevated in an array of cardiometabolic diseases. Here we demonstrate that the major metabolic fate of uniformly-(13)C-labeled α-ketoisovalerate ([U-(13)C]KIV) in the heart is reamination to valine. Activation of cardiac bran...
में बचाया:
| में प्रकाशित: | Nat Commun |
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| मुख्य लेखकों: | , , , , , , , , , , , , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Nature Publishing Group UK
2021
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7960706/ https://ncbi.nlm.nih.gov/pubmed/33723250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21962-2 |
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