Induction of Oxidative Stress in Trypanosoma brucei by the Antitrypanosomal Dihydroquinoline OSU-40

por He, Shanshan, Dayton, Alex, Kuppusamy, Periannan, Werbovetz, Karl A., Drew, Mark E.
Publicado 2012

Imidazoles as Potential Anticancer Agents: An Update on Recent Studies

por Sharma, Pankaj, LaRosa, Chris, Antwi, Janet, Govindarajan, Rajgopal, Werbovetz, Karl A.
Publicado en Molecules (2021)

Leishmania tarentolae: Purification and characterization of tubulin and its suitability for antileishmanial drug screening

por Yakovich, Adam J., Ragone, Frank L., Alfonzo, Juan D., Sackett, Dan L., Werbovetz, Karl A.
Publicado 2006

Studies on the Antileishmanial Mechanism of Action of the Arylimidamide DB766: Azole Interactions and Role of CYP5122A1

por Pandharkar, Trupti, Zhu, Xiaohua, Mathur, Radhika, Jiang, Jinmai, Schmittgen, Thomas D., Shaha, Chandrima, Werbovetz, Karl A.
Publicado 2014

Evaluation of Antitrypanosomal Dihydroquinolines for Hepatotoxicity, Mutagenicity, and Methemoglobin Formation In Vitro

por Werbovetz, Karl A., Riccio, Edward S., Furimsky, Anna, Richard, Julian V., He, Shanshan, Iyer, Lalitha, Mirsalis, Jon
Publicado en Int J Toxicol (2014)

Correction for Pandharkar et al., “Studies on the Antileishmanial Mechanism of Action of the Arylimidamide DB766: Azole Interactions and Role of CYP5122A1”

por Pandharkar, Trupti, Zhu, Xiaohua, Mathur, Radhika, Jiang, Jinmai, Schmittgen, Thomas D., Shaha, Chandrima, Werbovetz, Karl A.
Publicado en Antimicrob Agents Chemother (2017)

SAR refinement of antileishmanial N(2),N(4)-disubstituted quinazoline-2,4-diamines

por Zhu, Xiaohua, Van Horn, Kurt S., Barber, Megan, Yang, Sihyung, Wang, Michael Zhuo, Manetsch, Roman, Werbovetz, Karl A.
Publicado en Bioorg Med Chem (2015)

α-Tubulin Mutations Alter Oryzalin Affinity and Microtubule Assembly Properties To Confer Dinitroaniline Resistance

por Lyons-Abbott, Sally, Sackett, Dan L., Wloga, Dorota, Gaertig, Jacek, Morgan, Rachel E., Werbovetz, Karl A., Morrissette, Naomi S.
Publicado 2010

Synthesis and Antiprotozoal Activity of Cationic 1,4-Diphenyl-1H-1,2,3-Triazoles

por Bakunov, Stanislav A., Bakunova, Svetlana M., Wenzler, Tanja, Ghebru, Maedot, Werbovetz, Karl A., Brun, Reto, Tidwell, Richard R.
Publicado 2010

Antileishmanial Activities of Several Classes of Aromatic Dications

por Brendle, James J., Outlaw, Abram, Kumar, Arvind, Boykin, David W., Patrick, Donald A., Tidwell, Richard R., Werbovetz, Karl A.
Publicado 2002

Synthesis and Evaluation of Oryzalin Analogs against Toxoplasma gondii

por Endeshaw, Molla M., Li, Catherine, de Leon, Jessica, Yao, Ni, Latibeaudiere, Kirk, Premalatha, Kokku, Morrissette, Naomi, Werbovetz, Karl A.
Publicado 2010

Antileishmanial Efficacy and Pharmacokinetics of DB766-Azole Combinations

por Joice, April C., Yang, Sihyung, Farahat, Abdelbasset A., Meeds, Heidi, Feng, Mei, Li, Junan, Boykin, David W., Wang, Michael Zhuo, Werbovetz, Karl A.
Publicado en Antimicrob Agents Chemother (2017)

Synthesis, DNA binding and antileishmanial activity of low molecular weight bis-arylimidamides

por Banerjee, Moloy, Farahat, Abdelbasset A., Kumar, Arvind, Wenzler, Tanja, Brun, Reto, Munde, Manoj M., Wilson, W. David, Zhu, Xiaohua, Werbovetz, Karl A., Boykin, David W.
Publicado 2012

Inhibitors of Tubulin Assembly Identified through Screening a Compound Library

por Morgan, Rachel E., Ahn, Sunjoo, Nzimiro, Sandra, Fotie, Jean, Phelps, Mitch A., Cotrill, Jeffrey, Yakovich, Adam J., Sackett, Dan L., Dalton, James T., Werbovetz, Karl A.
Publicado 2008

Synthesis, Biological Evaluation, and Molecular Modeling of 3,5-Substituted-N(1)-phenyl-N(4), N(4)-di-n-butylsulfanilamides as Antikinetoplastid Antimicrotubule Agents

por George, Tesmol G., Endeshaw, Molla M., Morgan, Rachel E., Mahasenan, Kiran V., Delfín, Dawn A., Mukherjee, Mitali S., Yakovich, Adam J., Fotie, Jean, Li, Chenglong, Werbovetz, Karl A.
Publicado 2007

Antileishmanial Activity of a Series of N(2),N(4)-Disubstituted Quinazoline-2,4-diamines

por Van Horn, Kurt S., Zhu, Xiaohua, Pandharkar, Trupti, Yang, Sihyung, Vesely, Brian, Vanaerschot, Manu, Dujardin, Jean-Claude, Rijal, Suman, Kyle, Dennis E., Wang, Michael Zhuo, Werbovetz, Karl A., Manetsch, Roman
Publicado 2014

Antileishmanial and Cytotoxic Activity of Some Highly Oxidized Abietane Diterpenoids from the Bald Cypress, Taxodium distichum

por Naman, C. Benjamin, Gromovsky, Anthony D., Vela, Cory M., Fletcher, Joshua N., Gupta, Gaurav, Varikuti, Sanjay, Zhu, Xiaohua, Zywot, Emilia M., Chai, Heebyung, Werbovetz, Karl A., Satoskar, Abhay R., Kinghorn, A. Douglas
Publicado en J Nat Prod (2016)

Synthesis and pharmacological evaluation of mono-arylimidamides as antileishmanial agents

por Zhu, Xiaohua, Farahat, Abdelbasset A., Mattamana, Meena, Joice, April, Pandharkar, Trupti, Holt, Elizabeth, Banerjee, Moloy, Gragg, Jamie L., Hu, Laixing, Kumar, Arvind, Yang, Sihyung, Wang, Michael Zhuo, Boykin, David W., Werbovetz, Karl A.
Publicado en Bioorg Med Chem Lett (2016)

Novel Arylimidamides for Treatment of Visceral Leishmaniasis

por Wang, Michael Zhuo, Zhu, Xiaohua, Srivastava, Anuradha, Liu, Qiang, Sweat, J. Mark, Pandharkar, Trupti, Stephens, Chad E., Riccio, Ed, Parman, Toufan, Munde, Manoj, Mandal, Swati, Madhubala, Rentala, Tidwell, Richard R., Wilson, W. David, Boykin, David W., Hall, James Edwin, Kyle, Dennis E., Werbovetz, Karl A.
Publicado 2010

Evaluation of Arylimidamides DB1955 and DB1960 as Candidates against Visceral Leishmaniasis and Chagas' Disease: In Vivo Efficacy, Acute Toxicity, Pharmacokinetics, and Toxicology...

por Zhu, Xiaohua, Liu, Qiang, Yang, Sihyung, Parman, Toufan, Green, Carol E., Mirsalis, Jon C., de Nazaré Correia Soeiro, Maria, Mello de Souza, Elen, da Silva, Cristiane França, da Gama Jaen Batista, Denise, Stephens, Chad E., Banerjee, Moloy, Farahat, Abdelbasset A., Munde, Manoj, Wilson, W. David, Boykin, David W., Wang, Michael Zhuo, Werbovetz, Karl A.
Publicado 2012