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Synthesis and Evaluation of Oryzalin Analogs against Toxoplasma gondii

The synthesis and evaluation of twenty dinitroanilines and related compounds against the obligate intracellular parasite Toxoplasma gondii is reported. Using in vitro cultures of parasites in human fibroblasts, we determined that most of these compounds selectively disrupted Toxoplasma microtubules,...

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Detalhes bibliográficos
Main Authors: Endeshaw, Molla M., Li, Catherine, de Leon, Jessica, Yao, Ni, Latibeaudiere, Kirk, Premalatha, Kokku, Morrissette, Naomi, Werbovetz, Karl A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922421/
https://ncbi.nlm.nih.gov/pubmed/20675138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.07.003
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