Synthesis and Evaluation of Oryzalin Analogs against Toxoplasma gondii

The synthesis and evaluation of twenty dinitroanilines and related compounds against the obligate intracellular parasite Toxoplasma gondii is reported. Using in vitro cultures of parasites in human fibroblasts, we determined that most of these compounds selectively disrupted Toxoplasma microtubules,...

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Autores principales: Endeshaw, Molla M., Li, Catherine, de Leon, Jessica, Yao, Ni, Latibeaudiere, Kirk, Premalatha, Kokku, Morrissette, Naomi, Werbovetz, Karl A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922421/
https://ncbi.nlm.nih.gov/pubmed/20675138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.07.003
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