Evaluation of Arylimidamides DB1955 and DB1960 as Candidates against Visceral Leishmaniasis and Chagas' Disease: In Vivo Efficacy, Acute Toxicity, Pharmacokinetics, and Toxicology Studies

Arylimidamides (AIAs) have shown outstanding in vitro potency against intracellular kinetoplastid parasites, and the AIA 2,5-bis[2-(2-propoxy)-4-(2-pyridylimino)aminophenyl]furan dihydrochloride (DB766) displayed good in vivo efficacy in rodent models of visceral leishmaniasis (VL) and Chagas'...

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Bibliografski detalji
Glavni autori: Zhu, Xiaohua, Liu, Qiang, Yang, Sihyung, Parman, Toufan, Green, Carol E., Mirsalis, Jon C., de Nazaré Correia Soeiro, Maria, Mello de Souza, Elen, da Silva, Cristiane França, da Gama Jaen Batista, Denise, Stephens, Chad E., Banerjee, Moloy, Farahat, Abdelbasset A., Munde, Manoj, Wilson, W. David, Boykin, David W., Wang, Michael Zhuo, Werbovetz, Karl A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Experimental Therapeutics
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393454/
https://ncbi.nlm.nih.gov/pubmed/22508306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06404-11
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