Evaluation of Arylimidamides DB1955 and DB1960 as Candidates against Visceral Leishmaniasis and Chagas' Disease: In Vivo Efficacy, Acute Toxicity, Pharmacokinetics, and Toxicology Studies

Arylimidamides (AIAs) have shown outstanding in vitro potency against intracellular kinetoplastid parasites, and the AIA 2,5-bis[2-(2-propoxy)-4-(2-pyridylimino)aminophenyl]furan dihydrochloride (DB766) displayed good in vivo efficacy in rodent models of visceral leishmaniasis (VL) and Chagas'...

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Bibliografische gegevens
Hoofdauteurs: Zhu, Xiaohua, Liu, Qiang, Yang, Sihyung, Parman, Toufan, Green, Carol E., Mirsalis, Jon C., de Nazaré Correia Soeiro, Maria, Mello de Souza, Elen, da Silva, Cristiane França, da Gama Jaen Batista, Denise, Stephens, Chad E., Banerjee, Moloy, Farahat, Abdelbasset A., Munde, Manoj, Wilson, W. David, Boykin, David W., Wang, Michael Zhuo, Werbovetz, Karl A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2012
Onderwerpen:
Experimental Therapeutics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393454/
https://ncbi.nlm.nih.gov/pubmed/22508306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06404-11
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