Phenotypic evaluation and in silico ADMET properties of novel arylimidamides in acute mouse models of Trypanosoma cruzi infection

Arylimidamides (AIAs), previously termed as reversed amidines, present a broad spectrum of activity against intracellular microorganisms. In the present study, three novel AIAs were evaluated in a mouse model of Trypanosoma cruzi infection, which is the causative agent of Chagas disease. The bis-AIA...

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Vydáno v:Drug Des Devel Ther
Hlavní autoři: da Silva, Cristiane França, Batista, Denise da Gama Jaén, de Araújo, Julianna Siciliano, Cunha-Junior, Edézio Ferreira, Stephens, Chad E, Banerjee, Moloy, Farahat, Abdelbasset A, Akay, Senol, Fisher, Mary K, Boykin, David W, Soeiro, Maria de Nazaré Correia
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2017
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388221/
https://ncbi.nlm.nih.gov/pubmed/28435221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S120618
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