In Vitro and In Vivo Studies of the Biological Activity of Novel Arylimidamides against Trypanosoma cruzi

Fifteen novel arylimidamides (AIAs) (6 bis-amidino and 9 mono-amidino analogues) were assayed against Trypanosoma cruzi in vitro and in vivo. All the bis-AIAs were more effective than the mono-AIAs, and two analogues, DB1967 and DB1989, were further evaluated in vivo. Although both of them reduced p...

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Main Authors: De Araújo, J. S., Da Silva, C. F., Batista, D. G. J., Da Silva, P. B., Meuser, M. B., Aiub, C. A. F., da Silva, M. F. V., Araújo-Lima, C. F., Banerjee, M., Farahat, A. A., Stephens, C. E., Kumar, A., Boykin, D. W., Soeiro, M. N. C.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2014
主題:
Experimental Therapeutics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068551/
https://ncbi.nlm.nih.gov/pubmed/24590476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01403-13
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