Hypercapnia Regulates Gene Expression and Tissue Function

Por Shigemura, Masahiko, Welch, Lynn C., Sznajder, Jacob I.
Publicado no Front Physiol (2020)

Carbonic Anhydrase II and Alveolar Fluid Reabsorption during Hypercapnia

Por Chen, Jiwang, Lecuona, Emilia, Briva, Arturo, Welch, Lynn C., Sznajder, Jacob I.
Publicado em 2008

The Hlx homeobox transcription factor is required early in enteric nervous system development

Por Bates, Michael D, Dunagan, Dana T, Welch, Lynn C, Kaul, Ajay, Harvey, Richard P
Publicado em 2006

Salt-inducible kinase 1 is present in lung alveolar epithelial cells and regulates active sodium transport

Por Eneling, Kristina, Chen, Jiwang, Welch, Lynn C., Takemori, Hiroshi, Sznajder, Jacob I., Bertorello, Alejandro M.
Publicado em 2011

Phosphorylation and ubiquitination are necessary for Na,K-ATPase endocytosis during hypoxia

Por Dada, Laura A., Welch, Lynn C., Zhou, Guofei, Ben-Saadon, Ronen, Ciechanover, Aaron, Sznajder, Jacob I.
Publicado em 2007

Extracellular signal-regulated kinase (ERK) participates in the hypercapnia-induced Na,K-ATPase downregulation

Por Welch, Lynn C., Lecuona, Emilia, Briva, Arturo, Trejo, Humberto E., Dada, Laura A., Sznajder, Jacob I.
Publicado em 2010

Cardiac glycosides decrease influenza virus replication by inhibiting cell protein translational machinery

Por Amarelle, Luciano, Katzen, Jeremy, Shigemura, Masahiko, Welch, Lynn C., Cajigas, Héctor, Peteranderl, Christin, Celli, Diego, Herold, Susanne, Lecuona, Emilia, Sznajder, Jacob I.
Publicado no Am J Physiol Lung Cell Mol Physiol (2019)

Elevated CO(2) Levels Delay Skeletal Muscle Repair by Increasing Fatty Acid Oxidation

Por Ceco, Ermelinda, Celli, Diego, Weinberg, Samuel, Shigemura, Masahiko, Welch, Lynn C., Volpe, Lena, Chandel, Navdeep S., Bharat, Ankit, Lecuona, Emilia, Sznajder, Jacob I.
Publicado no Front Physiol (2021)

Hypercapnia Impairs Lung Neutrophil Function and Increases Mortality in Murine Pseudomonas Pneumonia

Por Gates, Khalilah L., Howell, Heather A., Nair, Aisha, Vohwinkel, Christine U., Welch, Lynn C., Beitel, Greg J., Hauser, Alan R., Sznajder, Jacob I., Sporn, Peter H. S.
Publicado em 2013

Hypoxia Leads to Na,K-ATPase Downregulation via Ca(2+) Release-Activated Ca(2+) Channels and AMPK Activation

Por Gusarova, Galina A., Trejo, Humberto E., Dada, Laura A., Briva, Arturo, Welch, Lynn C., Hamanaka, Robert B., Mutlu, Gökhan M., Chandel, Navdeep S., Prakriya, Murali, Sznajder, Jacob I.
Publicado em 2011

Airborne Particulate Matter Inhibits Alveolar Fluid Reabsorption in Mice via Oxidant Generation

Por Mutlu, Gökhan M., Snyder, Colleen, Bellmeyer, Amy, Wang, Helena, Hawkins, Keenan, Soberanes, Saul, Welch, Lynn C., Ghio, Andrew J., Chandel, Navdeep S., Kamp, David, Sznajder, Jacob I., Budinger, G. R. Scott
Publicado em 2006

Myosin-Va restrains the trafficking of Na(+)/K(+)-ATPase-containing vesicles in alveolar epithelial cells

Por Lecuona, Emilia, Minin, Alexander, Trejo, Humberto E., Chen, Jiwang, Comellas, Alejandro P., Sun, Haiying, Grillo, Doris, Nekrasova, Oxana E., Welch, Lynn C., Szleifer, Igal, Gelfand, Vladimir I., Sznajder, Jacob I.
Publicado em 2009

High CO(2) Levels Impair Alveolar Epithelial Function Independently of pH

Por Briva, Arturo, Vadász, István, Lecuona, Emilia, Welch, Lynn C., Chen, Jiwang, Dada, Laura A., Trejo, Humberto E., Dumasius, Vidas, Azzam, Zaher S., Myrianthefs, Pavlos M., Batlle, Daniel, Gruenbaum, Yosef, Sznajder, Jacob I.
Publicado em 2007

AMP-activated protein kinase regulates CO(2)-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis

Por Vadász, István, Dada, Laura A., Briva, Arturo, Trejo, Humberto E., Welch, Lynn C., Chen, Jiwang, Tóth, Péter T., Lecuona, Emilia, Witters, Lee A., Schumacker, Paul T., Chandel, Navdeep S., Seeger, Werner, Sznajder, Jacob I.
Publicado em 2008

High CO(2) Levels Impair Lung Wound Healing

Por Bharat, Ankit, Angulo, Martín, Sun, Haiying, Akbarpour, Mahzad, Alberro, Andrés, Cheng, Yuan, Shigemura, Masahiko, Berdnikovs, Sergejs, Welch, Lynn C., Kanter, Jacob A., Budinger, G. R. Scott, Lecuona, Emilia, Sznajder, Jacob I.
Publicado no Am J Respir Cell Mol Biol (2020)

High CO(2) Levels Cause Skeletal Muscle Atrophy via AMP-activated Kinase (AMPK), FoxO3a Protein, and Muscle-specific Ring Finger Protein 1 (MuRF1)

Por Jaitovich, Ariel, Angulo, Martín, Lecuona, Emilia, Dada, Laura A., Welch, Lynn C., Cheng, Yuan, Gusarova, Galina, Ceco, Ermelinda, Liu, Chang, Shigemura, Masahiko, Barreiro, Esther, Patterson, Cam, Nader, Gustavo A., Sznajder, Jacob I.
Publicado no J Biol Chem (2015)

Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia

Por Selfridge, Andrew C., Cavadas, Miguel A. S., Scholz, Carsten C., Campbell, Eric L., Welch, Lynn C., Lecuona, Emilia, Colgan, Sean P., Barrett, Kim E., Sporn, Peter H. S., Sznajder, Jacob I., Cummins, Eoin P., Taylor, Cormac T.
Publicado no J Biol Chem (2016)

Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling

Por Shigemura, Masahiko, Lecuona, Emilia, Angulo, Martín, Homma, Tetsuya, Rodríguez, Diego A., Gonzalez-Gonzalez, Francisco J., Welch, Lynn C., Amarelle, Luciano, Kim, Seok-Jo, Kaminski, Naftali, Budinger, G. R. Scott, Solway, Julian, Sznajder, Jacob I.
Publicado no Sci Transl Med (2018)

High CO(2) Leads to Na,K-ATPase Endocytosis via c-Jun Amino-Terminal Kinase-Induced LMO7b Phosphorylation

Por Dada, Laura A., Trejo Bittar, Humberto E., Welch, Lynn C., Vagin, Olga, Deiss-Yehiely, Nimrod, Kelly, Aileen M., Baker, Mairead R., Capri, Joseph, Cohn, Whitaker, Whitelegge, Julian P., Vadász, István, Gruenbaum, Yosef, Sznajder, Jacob I.
Publicado no Mol Cell Biol (2015)

Evolutionary Conserved Role of c-Jun-N-Terminal Kinase in CO(2)-Induced Epithelial Dysfunction

Por Vadász, István, Dada, Laura A., Briva, Arturo, Helenius, Iiro Taneli, Sharabi, Kfir, Welch, Lynn C., Kelly, Aileen M., Grzesik, Benno A., Budinger, G. R. Scott, Liu, Jing, Seeger, Werner, Beitel, Greg J., Gruenbaum, Yosef, Sznajder, Jacob I.
Publicado em 2012