Extracellular signal-regulated kinase (ERK) participates in the hypercapnia-induced Na,K-ATPase downregulation

Hypercapnia has been shown to impair alveolar fluid reabsorption (AFR) by decreasing Na,K-ATPase activity. Extracellular signal-regulated kinase pathway (ERK) is activated under conditions of cellular stress and has been known to regulate the Na,K-ATPase. Here, we show that hypercapnia leads to ERK...

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Hauptverfasser: Welch, Lynn C., Lecuona, Emilia, Briva, Arturo, Trejo, Humberto E., Dada, Laura A., Sznajder, Jacob I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966388/
https://ncbi.nlm.nih.gov/pubmed/20691686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.08.002
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