AMP-activated protein kinase regulates CO(2)-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis

Hypercapnia (elevated CO(2) levels) occurs as a consequence of poor alveolar ventilation and impairs alveolar fluid reabsorption (AFR) by promoting Na,K-ATPase endocytosis. We studied the mechanisms regulating CO(2)-induced Na,K-ATPase endocytosis in alveolar epithelial cells (AECs) and alveolar epi...

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Hauptverfasser: Vadász, István, Dada, Laura A., Briva, Arturo, Trejo, Humberto E., Welch, Lynn C., Chen, Jiwang, Tóth, Péter T., Lecuona, Emilia, Witters, Lee A., Schumacker, Paul T., Chandel, Navdeep S., Seeger, Werner, Sznajder, Jacob I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2008
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2176184/
https://ncbi.nlm.nih.gov/pubmed/18188452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29723
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