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AMP-activated protein kinase regulates CO(2)-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis
Hypercapnia (elevated CO(2) levels) occurs as a consequence of poor alveolar ventilation and impairs alveolar fluid reabsorption (AFR) by promoting Na,K-ATPase endocytosis. We studied the mechanisms regulating CO(2)-induced Na,K-ATPase endocytosis in alveolar epithelial cells (AECs) and alveolar epi...
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2176184/ https://ncbi.nlm.nih.gov/pubmed/18188452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29723 |
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