Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-ζ

During ascent to high altitude and pulmonary edema, the alveolar epithelial cells (AEC) are exposed to hypoxic conditions. Hypoxia inhibits alveolar fluid reabsorption and decreases Na,K-ATPase activity in AEC. We report here that exposure of AEC to hypoxia induced a time-dependent decrease of Na,K-...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Dada, Laura A., Chandel, Navdeep S., Ridge, Karen M., Pedemonte, Carlos, Bertorello, Alejandro M., Sznajder, Jacob I.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 2003
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152585/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12671055/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI16826
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