Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-ζ

During ascent to high altitude and pulmonary edema, the alveolar epithelial cells (AEC) are exposed to hypoxic conditions. Hypoxia inhibits alveolar fluid reabsorption and decreases Na,K-ATPase activity in AEC. We report here that exposure of AEC to hypoxia induced a time-dependent decrease of Na,K-...

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Detalhes bibliográficos
Main Authors: Dada, Laura A., Chandel, Navdeep S., Ridge, Karen M., Pedemonte, Carlos, Bertorello, Alejandro M., Sznajder, Jacob I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC152585/
https://ncbi.nlm.nih.gov/pubmed/12671055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316826
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