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Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

Philadelphia chromosome-positive leukemias result from the fusion of the BCR and ABL genes, which generates a functional chimeric molecule. The Abr protein is very similar to Bcr but lacks a structural domain which may influence its biological regulatory capabilities. Both Abr and Bcr have a GTPase-...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Chuang, T H, Xu, X, Kaartinen, V, Heisterkamp, N, Groffen, J, Bokoch, G M
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40780/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479768/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.22.10282
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