Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-ζ

During ascent to high altitude and pulmonary edema, the alveolar epithelial cells (AEC) are exposed to hypoxic conditions. Hypoxia inhibits alveolar fluid reabsorption and decreases Na,K-ATPase activity in AEC. We report here that exposure of AEC to hypoxia induced a time-dependent decrease of Na,K-...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Dada, Laura A., Chandel, Navdeep S., Ridge, Karen M., Pedemonte, Carlos, Bertorello, Alejandro M., Sznajder, Jacob I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2003
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC152585/
https://ncbi.nlm.nih.gov/pubmed/12671055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316826
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge