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Protein Kinase A-Iα Regulates Na,K-ATPase Endocytosis in Alveolar Epithelial Cells Exposed to High CO(2) Concentrations

Elevated concentrations of CO(2) (hypercapnia) lead to alveolar epithelial dysfunction by promoting Na,K-ATPase endocytosis. In the present report, we investigated whether the CO(2)/HCO(3)(−) activated soluble adenylyl cyclase (sAC) regulates this process. We found that hypercapnia increased the pro...

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Bibliografiske detaljer
Main Authors: Lecuona, Emilia, Sun, Haiying, Chen, Jiwang, Trejo, Humberto E., Baker, Margaret A., Sznajder, Jacob I.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707378/
https://ncbi.nlm.nih.gov/pubmed/23349050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0373OC
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