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Hypoxia Leads to Na,K-ATPase Downregulation via Ca(2+) Release-Activated Ca(2+) Channels and AMPK Activation
To maintain cellular ATP levels, hypoxia leads to Na,K-ATPase inhibition in a process dependent on reactive oxygen species (ROS) and the activation of AMP-activated kinase α1 (AMPK-α1). We report here that during hypoxia AMPK activation does not require the liver kinase B1 (LKB1) but requires the re...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society for Microbiology
2011
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3165547/ https://ncbi.nlm.nih.gov/pubmed/21730292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05114-11 |
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