Hypoxia Leads to Na,K-ATPase Downregulation via Ca(2+) Release-Activated Ca(2+) Channels and AMPK Activation

To maintain cellular ATP levels, hypoxia leads to Na,K-ATPase inhibition in a process dependent on reactive oxygen species (ROS) and the activation of AMP-activated kinase α1 (AMPK-α1). We report here that during hypoxia AMPK activation does not require the liver kinase B1 (LKB1) but requires the re...

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Detalhes bibliográficos
Main Authors: Gusarova, Galina A., Trejo, Humberto E., Dada, Laura A., Briva, Arturo, Welch, Lynn C., Hamanaka, Robert B., Mutlu, Gökhan M., Chandel, Navdeep S., Prakriya, Murali, Sznajder, Jacob I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165547/
https://ncbi.nlm.nih.gov/pubmed/21730292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05114-11
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