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Divergence of Ca(2+) selectivity and equilibrium Ca(2+) blockade in a Ca(2+) release-activated Ca(2+) channel

Prevailing models postulate that high Ca(2+) selectivity of Ca(2+) release-activated Ca(2+) (CRAC) channels arises from tight Ca(2+) binding to a high affinity site within the pore, thereby blocking monovalent ion flux. Here, we examined the contribution of high affinity Ca(2+) binding for Ca(2+) se...

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Bibliografske podrobnosti
Main Authors: Yamashita, Megumi, Prakriya, Murali
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3933933/
https://ncbi.nlm.nih.gov/pubmed/24567508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201311108
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