α1-AMP-Activated Protein Kinase Regulates Hypoxia-Induced Na,K-ATPase Endocytosis via Direct Phosphorylation of Protein Kinase Cζ

Hypoxia promotes Na,K-ATPase endocytosis via protein kinase Cζ (PKCζ)-mediated phosphorylation of the Na,K-ATPase α subunit. Here, we report that hypoxia leads to the phosphorylation of 5′-AMP-activated protein kinase (AMPK) at Thr172 in rat alveolar epithelial cells. The overexpression of a dominan...

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Autores principales: Gusarova, Galina A., Dada, Laura A., Kelly, Aileen M., Brodie, Chaya, Witters, Lee A., Chandel, Navdeep S., Sznajder, Jacob I.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2009
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698765/
https://ncbi.nlm.nih.gov/pubmed/19380482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00054-09
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