High CO(2) Levels Cause Skeletal Muscle Atrophy via AMP-activated Kinase (AMPK), FoxO3a Protein, and Muscle-specific Ring Finger Protein 1 (MuRF1)

Patients with chronic obstructive pulmonary disease, acute lung injury, and critical care illness may develop hypercapnia. Many of these patients often have muscle dysfunction which increases morbidity and impairs their quality of life. Here, we investigated whether hypercapnia leads to skeletal mus...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Jaitovich, Ariel, Angulo, Martín, Lecuona, Emilia, Dada, Laura A., Welch, Lynn C., Cheng, Yuan, Gusarova, Galina, Ceco, Ermelinda, Liu, Chang, Shigemura, Masahiko, Barreiro, Esther, Patterson, Cam, Nader, Gustavo A., Sznajder, Jacob I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423704/
https://ncbi.nlm.nih.gov/pubmed/25691571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.625715
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