High CO(2) Levels Cause Skeletal Muscle Atrophy via AMP-activated Kinase (AMPK), FoxO3a Protein, and Muscle-specific Ring Finger Protein 1 (MuRF1)

Patients with chronic obstructive pulmonary disease, acute lung injury, and critical care illness may develop hypercapnia. Many of these patients often have muscle dysfunction which increases morbidity and impairs their quality of life. Here, we investigated whether hypercapnia leads to skeletal mus...

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Vydáno v:J Biol Chem
Hlavní autoři: Jaitovich, Ariel, Angulo, Martín, Lecuona, Emilia, Dada, Laura A., Welch, Lynn C., Cheng, Yuan, Gusarova, Galina, Ceco, Ermelinda, Liu, Chang, Shigemura, Masahiko, Barreiro, Esther, Patterson, Cam, Nader, Gustavo A., Sznajder, Jacob I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423704/
https://ncbi.nlm.nih.gov/pubmed/25691571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.625715
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