Evolutionary Conserved Role of c-Jun-N-Terminal Kinase in CO(2)-Induced Epithelial Dysfunction

Elevated CO(2) levels (hypercapnia) occur in patients with respiratory diseases and impair alveolar epithelial integrity, in part, by inhibiting Na,K-ATPase function. Here, we examined the role of c-Jun N-terminal kinase (JNK) in CO(2) signaling in mammalian alveolar epithelial cells as well as in d...

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Main Authors: Vadász, István, Dada, Laura A., Briva, Arturo, Helenius, Iiro Taneli, Sharabi, Kfir, Welch, Lynn C., Kelly, Aileen M., Grzesik, Benno A., Budinger, G. R. Scott, Liu, Jing, Seeger, Werner, Beitel, Greg J., Gruenbaum, Yosef, Sznajder, Jacob I.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466313/
https://ncbi.nlm.nih.gov/pubmed/23056407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046696
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