Evolutionary Conserved Role of c-Jun-N-Terminal Kinase in CO(2)-Induced Epithelial Dysfunction

Elevated CO(2) levels (hypercapnia) occur in patients with respiratory diseases and impair alveolar epithelial integrity, in part, by inhibiting Na,K-ATPase function. Here, we examined the role of c-Jun N-terminal kinase (JNK) in CO(2) signaling in mammalian alveolar epithelial cells as well as in d...

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Hauptverfasser: Vadász, István, Dada, Laura A., Briva, Arturo, Helenius, Iiro Taneli, Sharabi, Kfir, Welch, Lynn C., Kelly, Aileen M., Grzesik, Benno A., Budinger, G. R. Scott, Liu, Jing, Seeger, Werner, Beitel, Greg J., Gruenbaum, Yosef, Sznajder, Jacob I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466313/
https://ncbi.nlm.nih.gov/pubmed/23056407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046696
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