Targeting SIRPα in cancer

door Ho, Jenny M., Danska, Jayne S., Wang, Jean C.Y.
Gepubliceerd in 2013

Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice

door Bhatia, Mickie, Wang, Jean C. Y., Kapp, Ursula, Bonnet, Dominique, Dick, John E.
Gepubliceerd in 1997

Quantitative Analysis Reveals Expansion of Human Hematopoietic Repopulating Cells After Short-term Ex Vivo Culture

door Bhatia, Mickie, Bonnet, Dominique, Kapp, Ursula, Wang, Jean C.Y., Murdoch, Barbara, Dick, John E.
Gepubliceerd in 1997

CD47-SIRPα Interactions Regulate Macrophage Uptake of Plasmodium falciparum-Infected Erythrocytes and Clearance of Malaria In Vivo

door Ayi, Kodjo, Lu, Ziyue, Serghides, Lena, Ho, Jenny M., Finney, Constance, Wang, Jean C. Y., Liles, W. Conrad, Kain, Kevin C.
Gepubliceerd in Infect Immun (2016)

Leukemic stem cell signatures identify novel therapeutics targeting acute myeloid leukemia

door Laverdière, Isabelle, Boileau, Meaghan, Neumann, Andrea L., Frison, Héloïse, Mitchell, Amanda, Ng, Stanley W. K., Wang, Jean C. Y., Minden, Mark D., Eppert, Kolja
Gepubliceerd in Blood Cancer J (2018)

SIRPαFc treatment targets human acute myeloid leukemia stem cells

door Galkin, Oleksandr, McLeod, Jessica, Kennedy, James A., Jin, Liqing, Mbong, Nathan, Wong, Mark, Uger, Robert A., Minden, Mark D., Danska, Jayne S., Wang, Jean C.Y.
Gepubliceerd in Haematologica (2020)

CD200 expression marks leukemia stem cells in human AML

door Ho, Jenny M., Dobson, Stephanie M., Voisin, Veronique, McLeod, Jessica, Kennedy, James A., Mitchell, Amanda, Jin, Liqing, Eppert, Kolja, Bader, Gary, Minden, Mark D., Dick, John E., Wang, Jean C. Y.
Gepubliceerd in Blood Adv (2020)

Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts

door Theocharides, Alexandre P.A., Jin, Liqing, Cheng, Po-Yan, Prasolava, Tatiana K., Malko, Andrei V., Ho, Jenny M., Poeppl, Armando G., van Rooijen, Nico, Minden, Mark D., Danska, Jayne S., Dick, John E., Wang, Jean C.Y.
Gepubliceerd in 2012

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

door Schenk, Tino, Chen, Weihsu Claire, Göllner, Stefanie, Howell, Louise, Jin, Liqing, Hebestreit, Katja, Klein, Hans-Ulrich, Popescu, Andreea C, Burnett, Alan, Mills, Ken, Casero, Robert A, Marton, Laurence, Woster, Patrick, Minden, Mark D, Dugas, Martin, Wang, Jean C Y, Dick, John E, Müller-Tidow, Carsten, Petrie, Kevin, Zelent, Arthur
Gepubliceerd in 2012

CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells

door Surka, Christine, Jin, Liqing, Mbong, Nathan, Lu, Chin-Chun, Jang, In Sock, Rychak, Emily, Mendy, Derek, Clayton, Thomas, Tindall, Elizabeth, Hsu, Christy, Fontanillo, Celia, Tran, Eileen, Contreras, Adrian, Ng, Stanley W. K., Matyskiela, Mary, Wang, Kai, Chamberlain, Philip, Cathers, Brian, Carmichael, James, Hansen, Joshua, Wang, Jean C. Y., Minden, Mark D., Fan, Jinhong, Pierce, Daniel W., Pourdehnad, Michael, Rolfe, Mark, Lopez-Girona, Antonia, Dick, John E., Lu, Gang
Gepubliceerd in Blood (2021)

INHIBITION OF MITOCHONDRIAL TRANSLATION AS A THERAPEUTIC STRATEGY FOR HUMAN ACUTE MYELOID LEUKEMIA

door Škrtić, Marko, Sriskanthadevan, Shrivani, Jhas, Bozhena, Gebbia, Marinella, Wang, Xiaoming, Wang, Zezhou, Hurren, Rose, Jitkova, Yulia, Gronda, Marcela, Maclean, Neil, Lai, Courteney K., Eberhard, Yanina, Bartoszko, Justyna, Spagnuolo, Paul, Rutledge, Angela C., Datti, Alessandro, Ketela, Troy, Moffat, Jason, Robinson, Brian H., Cameron, Jessie H., Wrana, Jeffery, Eaves, Connie J., Minden, Mark D., Wang, Jean C.Y., Dick, John E., Humphries, Keith, Nislow, Corey, Giaever, Guri, Schimmer, Aaron D.
Gepubliceerd in 2011

Identification of pre-leukemic hematopoietic stem cells in acute leukemia

door Shlush, Liran I., Zandi, Sasan, Mitchell, Amanda, Chen, Weihsu Claire, Brandwein, Joseph M., Gupta, Vikas, Kennedy, James A., Schimmer, Aaron D., Schuh, Andre C., Yee, Karen W., McLeod, Jessica L., Doedens, Monica, Medeiros, Jessie J.F., Marke, Rene, Kim, Hyeoung Joon, Lee, Kwon, McPherson, John D., Hudson, Thomas J., Brown, Andrew M.K., Trinh, Quang M., Stein, Lincoln D., Minden, Mark D., Wang, Jean C.Y., Dick, John E.
Gepubliceerd in Nature (2014)

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells

door Lechman, Eric R., Gentner, Bernhard, Ng, Stanley W.K., Schoof, Erwin M., van Galen, Peter, Kennedy, James A., Nucera, Silvia, Ciceri, Fabio, Kaufmann, Kerstin B., Takayama, Naoya, Dobson, Stephanie M., Trotman-Grant, Aaron, Krivdova, Gabriela, Elzinga, Janneke, Mitchell, Amanda, Nilsson, Björn, Hermans, Karin G., Eppert, Kolja, Marke, Rene, Isserlin, Ruth, Voisin, Veronique, Bader, Gary D., Zandstra, Peter W., Golub, Todd R., Ebert, Benjamin L., Lu, Jun, Minden, Mark, Wang, Jean C.Y., Naldini, Luigi, Dick, John E.
Gepubliceerd in Cancer Cell (2016)

Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells

door Nieborowska-Skorska, Margaret, Sullivan, Katherine, Dasgupta, Yashodhara, Podszywalow-Bartnicka, Paulina, Hoser, Grazyna, Maifrede, Silvia, Martinez, Esteban, Di Marcantonio, Daniela, Bolton-Gillespie, Elisabeth, Cramer-Morales, Kimberly, Lee, Jaewong, Li, Min, Slupianek, Artur, Gritsyuk, Daniel, Cerny-Reiterer, Sabine, Seferynska, Ilona, Stoklosa, Tomasz, Bullinger, Lars, Zhao, Huaqing, Gorbunova, Vera, Piwocka, Katarzyna, Valent, Peter, Civin, Curt I., Muschen, Markus, Dick, John E., Wang, Jean C.Y., Bhatia, Smita, Bhatia, Ravi, Eppert, Kolja, Minden, Mark D., Sykes, Stephen M., Skorski, Tomasz
Gepubliceerd in J Clin Invest (2017)

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells

door Lechman, Eric R., Gentner, Bernhard, Ng, Stanley W.K., Schoof, Erwin M., van Galen, Peter, Kennedy, James A., Nucera, Silvia, Ciceri, Fabio, Kaufmann, Kerstin B., Takayama, Naoya, Dobson, Stephanie M., Trotman-Grant, Aaron, Krivdova, Gabriela, Elzinga, Janneke, Mitchell, Amanda, Nilsson, Björn, Hermans, Karin G., Eppert, Kolja, Marke, Rene, Isserlin, Ruth, Voisin, Veronique, Bader, Gary D., Zandstra, Peter W., Golub, Todd R., Ebert, Benjamin L., Lu, Jun, Minden, Mark, Wang, Jean C.Y., Naldini, Luigi, Dick, John E.
Gepubliceerd in Cancer Cell (2016)

Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation

door Xie, Stephanie Z., Kaufmann, Kerstin B., Wang, Weijia, Chan-Seng-Yue, Michelle, Gan, Olga I., Laurenti, Elisa, Garcia-Prat, Laura, Takayanagi, Shin-ichiro, Ng, Stanley W.K., Xu, ChangJiang, Zeng, Andy G.X., Jin, Liqing, McLeod, Jessica, Wagenblast, Elvin, Mitchell, Amanda, Kennedy, James A., Liu, Qiang, Boutzen, Héléna, Kleinau, Melissa, Jargstorf, Joseph, Holmes, Gareth, Zhang, Yang, Voisin, Veronique, Bader, Gary D., Wang, Jean C.Y., Hannun, Yusuf A., Luberto, Chiara, Schroeder, Timm, Minden, Mark D., Dick, John E.
Gepubliceerd in Blood Cancer Discov (2020)

Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors

door Sukhai, Mahadeo A., Prabha, Swayam, Hurren, Rose, Rutledge, Angela C., Lee, Anna Y., Sriskanthadevan, Shrivani, Sun, Hong, Wang, Xiaoming, Skrtic, Marko, Seneviratne, Ayesh, Cusimano, Maria, Jhas, Bozhena, Gronda, Marcela, MacLean, Neil, Cho, Eunice E., Spagnuolo, Paul A., Sharmeen, Sumaiya, Gebbia, Marinella, Urbanus, Malene, Eppert, Kolja, Dissanayake, Dilan, Jonet, Alexia, Dassonville-Klimpt, Alexandra, Li, Xiaoming, Datti, Alessandro, Ohashi, Pamela S., Wrana, Jeff, Rogers, Ian, Sonnet, Pascal, Ellis, William Y., Corey, Seth J., Eaves, Connie, Minden, Mark D., Wang, Jean C.Y., Dick, John E., Nislow, Corey, Giaever, Guri, Schimmer, Aaron D.
Gepubliceerd in 2012

Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leuekmia

door Cole, Alicia, Wang, Zezhou, Coyaud, Etienne, Voisin, Veronique, Gronda, Marcela, Jitkova, Yulia, Mattson, Rachel, Hurren, Rose, Babovic, Sonja, Maclean, Neil, Restall, Ian, Wang, Xiaoming, Jeyaraju, Danny V., Sukhai, Mahadeo A., Prabha, Swayam, Bashir, Shaheena, Ramakrishnan, Ashwin, Leung, Elisa, Qia, Yi Hua, Zhang, Nianxian, Combes, Kevin R., Ketela, Troy, Lin, Fengshu, Houry, Walid A., Aman, Ahmed, Al-awar, Rima, Zheng, Wei, Wienholds, Erno, Xu, Chang Jiang, Dick, John, Wang, Jean C.Y., Moffat, Jason, Minden, Mark D., Eaves, Connie J., Bader, Gary D., Hao, Zhenyue, Kornblau, Steven M., Raught, Brian, Schimmer, Aaron D.
Gepubliceerd in Cancer Cell (2015)

Prediction of acute myeloid leukaemia risk in healthy individuals

door Abelson, Sagi, Collord, Grace, Ng, Stanley W.K., Weissbrod, Omer, Cohen, Netta Mendelson, Niemeyer, Elisabeth, Barda, Noam, Zuzarte, Philip C., Heisler, Lawrence, Sundaravadanam, Yogi, Luben, Robert, Hayat, Shabina, Wang, Ting Ting, Zhao, Zhen, Cirlan, Iulia, Pugh, Trevor J., Soave, David, Ng, Karen, Latimer, Calli, Hardy, Claire, Raine, Keiran, Jones, David, Hoult, Diana, Britten, Abigail, McPherson, John D., Johansson, Mattias, Mbabaali, Faridah, Eagles, Jenna, Miller, Jessica, Pasternack, Danielle, Timms, Lee, Krzyzanowski, Paul, Awadalla, Phillip, Costa, Rui, Segal, Eran, Bratman, Scott V., Beer, Philip, Behjati, Sam, Martincorena, Inigo, Wang, Jean C.Y., Bowles, Kristian M., Quirós, J Ramón, Karakatsani, Anna, La Vecchia, Carlo, Trichopoulou, Antonia, Salamanca-Fernández, Elena, Huerta, José M., Barricarte, Aurelio, Travis, Ruth C., Tumino, Rosario, Masala, Giovanna, Boeing, Heiner, Panico, Salvatore, Kaaks, Rudolf, Krämer, Alwin, Sieri, Sabina, Riboli, Elio, Vineis, Paolo, Foll, Matthieu, McKay, James, Polidoro, Silvia, Sala, Núria, Khaw, Kay-Tee, Vermeulen, Roel, Campbell, Peter J, Papaemmanuil, Elli, Minden, Mark D, Tanay, Amos, Balicer, Ran D, Wareham, Nicholas J, Gerstung, Moritz, Dick, John E., Brennan, Paul, Vassiliou, George S., Shlush, Liran I.
Gepubliceerd in Nature (2018)