Identification of pre-leukemic hematopoietic stem cells in acute leukemia

In acute myeloid leukemia (AML), the cell of origin, nature and biological consequences of initiating lesions and order of subsequent mutations remain poorly understood, as AML is typically diagnosed without observation of a pre-leukemic phase. Here, highly purified hematopoietic stem cells (HSC), p...

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Bibliografiset tiedot
Julkaisussa:Nature
Päätekijät: Shlush, Liran I., Zandi, Sasan, Mitchell, Amanda, Chen, Weihsu Claire, Brandwein, Joseph M., Gupta, Vikas, Kennedy, James A., Schimmer, Aaron D., Schuh, Andre C., Yee, Karen W., McLeod, Jessica L., Doedens, Monica, Medeiros, Jessie J.F., Marke, Rene, Kim, Hyeoung Joon, Lee, Kwon, McPherson, John D., Hudson, Thomas J., Brown, Andrew M.K., Trinh, Quang M., Stein, Lincoln D., Minden, Mark D., Wang, Jean C.Y., Dick, John E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991939/
https://ncbi.nlm.nih.gov/pubmed/24522528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13038
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