Authors’ Reply to Kamel et al.: “Effect of Age and Renal Function on Idarucizumab Pharmacokinetics and Idarucizumab-Mediated Reversal of Dabigatran Anticoagulant Activity in a Rand...

Por Glund, Stephan, Reilly, Paul, van Ryn, Joanne, Stangier, Joachim
Publicado no Clin Pharmacokinet (2016)

Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental...

Por Grottke, Oliver, van Ryn, Joanne, Spronk, Henri MH, Rossaint, Rolf
Publicado em 2014

Structure-guided residence time optimization of a dabigatran reversal agent

Por Schiele, Felix, van Ryn, Joanne, Litzenburger, Tobias, Ritter, Michael, Seeliger, Daniel, Nar, Herbert
Publicado no MAbs (2015)

Thrombin inhibition and cisplatin block tumor progression in ovarian cancer by alleviating the immunosuppressive microenvironment

Por Alexander, Eric T., Minton, Allyson R., Peters, Molly C., van Ryn, Joanne, Gilmour, Susan K.
Publicado no Oncotarget (2016)

Switching from enoxaparin to dabigatran etexilate: pharmacokinetics, pharmacodynamics, and safety profile

Por Clemens, Andreas, van Ryn, Joanne, Sennewald, Regina, Yamamura, Norio, Stangier, Joachim, Feuring, Martin, Härtter, Sebastian
Publicado em 2012

The Discovery of Dabigatran Etexilate

Por van Ryn, Joanne, Goss, Ashley, Hauel, Norbert, Wienen, Wolfgang, Priepke, Henning, Nar, Herbert, Clemens, Andreas
Publicado em 2013

Thrombin inhibition and cyclophosphamide synergistically block tumor progression and metastasis

Por Alexander, Eric T, Minton, Allyson R, Hayes, Candace S, Goss, Ashley, Van Ryn, Joanne, Gilmour, Susan K
Publicado no Cancer Biol Ther (2015)

The Renal Elimination Pathways of the Dabigatran Reversal Agent Idarucizumab and its Impact on Dabigatran Elimination

Por Glund, Stephan, Gan, Guanfa, Moschetti, Viktoria, Reilly, Paul, Honickel, Markus, Grottke, Oliver, Van Ryn, Joanne
Publicado no Clin Appl Thromb Hemost (2018)

Anti-inflammatory and anti-fibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease

Por Bogatkevich, Galina S., Ludwicka-Bradley, Anna, Nietert, Paul J., Akter, Tanjina, van Ryn, Joanne, Silver, Richard M.
Publicado em 2011

Characterization of Thrombin-Bound Dabigatran Effects on Protease-Activated Receptor-1 Expression and Signaling In Vitro

Por Chen, Buxin, Soto, Antonio G., Coronel, Luisa J., Goss, Ashley, van Ryn, Joanne, Trejo, JoAnn
Publicado no Mol Pharmacol (2015)

Volume replacement strategies do not impair the binding of dabigatran to idarucizumab: Porcine model of hemodilution

Por Grottke, Oliver, van Ryn, Joanne, Zentai, Christian, Gan, Guanfa, Honickel, Markus, Rossaint, Rolf, ten Cate, Hugo, Spronk, Henri M. H.
Publicado no PLoS One (2019)

Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice

Por Preusch, Michael R, Ieronimakis, Nicholas, Wijelath, Errol S, Cabbage, Sara, Ricks, Jerry, Bea, Florian, Reyes, Morayma, van Ryn, Joanne, Rosenfeld, Michael E
Publicado no Drug Des Devel Ther (2015)

Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease

Por Sparkenbaugh, Erica M., Chantrathammachart, Pichika, Mickelson, Jacqueline, van Ryn, Joanne, Hebbel, Robert P., Monroe, Dougald M., Mackman, Nigel, Key, Nigel S., Pawlinski, Rafal
Publicado em 2014

Effects of Dabigatran in Mouse Models of Aging and Cerebral Amyloid Angiopathy

Por Michael, Neethu, Grigoryan, Mher Mahoney, Kilday, Kelley, Sumbria, Rachita K., Vasilevko, Vitaly, van Ryn, Joanne, Cribbs, David H., Paganini-Hill, Annlia, Fisher, Mark J.
Publicado no Front Neurol (2019)

Effect of Age and Renal Function on Idarucizumab Pharmacokinetics and Idarucizumab-Mediated Reversal of Dabigatran Anticoagulant Activity in a Randomized, Double-Blind, Crossover P...

Por Glund, Stephan, Stangier, Joachim, van Ryn, Joanne, Schmohl, Michael, Moschetti, Viktoria, Haazen, Wouter, De Smet, Marina, Gansser, Dietmar, Norris, Stephen, Lang, Benjamin, Reilly, Paul, Kreuzer, Jörg
Publicado no Clin Pharmacokinet (2016)

Translational insights into traumatic brain injury occurring during dabigatran or warfarin anticoagulation

Por Schaefer, Jan Hendrik, Leung, Wendy, Wu, Limin, Van Cott, Elizabeth M, Lok, Josephine, Whalen, Michael, van Leyen, Klaus, Lauer, Arne, van Ryn, Joanne, Lo, Eng H, Foerch, Christian
Publicado em 2014

Thrombin promotes diet-induced obesity through fibrin-driven inflammation

Por Kopec, Anna K., Abrahams, Sara R., Thornton, Sherry, Palumbo, Joseph S., Mullins, Eric S., Divanovic, Senad, Weiler, Hartmut, Owens, A. Phillip, Mackman, Nigel, Goss, Ashley, van Ryn, Joanne, Luyendyk, James P., Flick, Matthew J.
Publicado no J Clin Invest (2017)

Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dep...

Por Borissoff, Julian I., Otten, Jeroen J. T., Heeneman, Sylvia, Leenders, Peter, van Oerle, René, Soehnlein, Oliver, Loubele, Sarah T. B. G., Hamulyák, Karly, Hackeng, Tilman M., Daemen, Mat J. A. P., Degen, Jay L., Weiler, Hartmut, Esmon, Charles T., van Ryn, Joanne, Biessen, Erik A. L., Spronk, Henri M. H., ten Cate, Hugo
Publicado em 2013