Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease

Activation of coagulation and vascular inflammation are prominent features of sickle cell disease (SCD). Previously, we have shown that inhibition of tissue factor (TF) attenuates activation of coagulation and vascular inflammation in mouse models of SCD. In this study, we examined the mechanism by...

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Detalhes bibliográficos
Main Authors: Sparkenbaugh, Erica M., Chantrathammachart, Pichika, Mickelson, Jacqueline, van Ryn, Joanne, Hebbel, Robert P., Monroe, Dougald M., Mackman, Nigel, Key, Nigel S., Pawlinski, Rafal
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954055/
https://ncbi.nlm.nih.gov/pubmed/24449213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-08-523936
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