Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease

Activation of coagulation and vascular inflammation are prominent features of sickle cell disease (SCD). Previously, we have shown that inhibition of tissue factor (TF) attenuates activation of coagulation and vascular inflammation in mouse models of SCD. In this study, we examined the mechanism by...

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Bibliographic Details
Main Authors: Sparkenbaugh, Erica M., Chantrathammachart, Pichika, Mickelson, Jacqueline, van Ryn, Joanne, Hebbel, Robert P., Monroe, Dougald M., Mackman, Nigel, Key, Nigel S., Pawlinski, Rafal
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2014
Subjects:
Thrombosis and Hemostasis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954055/
https://ncbi.nlm.nih.gov/pubmed/24449213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-08-523936
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