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Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease

Activation of coagulation and vascular inflammation are prominent features of sickle cell disease (SCD). Previously, we have shown that inhibition of tissue factor (TF) attenuates activation of coagulation and vascular inflammation in mouse models of SCD. In this study, we examined the mechanism by...

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Hlavní autoři: Sparkenbaugh, Erica M., Chantrathammachart, Pichika, Mickelson, Jacqueline, van Ryn, Joanne, Hebbel, Robert P., Monroe, Dougald M., Mackman, Nigel, Key, Nigel S., Pawlinski, Rafal
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954055/
https://ncbi.nlm.nih.gov/pubmed/24449213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-08-523936
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