Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model

INTRODUCTION: New oral anticoagulants are effective alternatives to warfarin. However, no specific reversal agents are available for life-threatening bleeding or emergency surgery. Using a porcine model of trauma, this study assessed the ability of prothrombin complex concentrate (PCC), activated PC...

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Bibliographic Details
Main Authors: Grottke, Oliver, van Ryn, Joanne, Spronk, Henri MH, Rossaint, Rolf
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059479/
https://ncbi.nlm.nih.gov/pubmed/24499559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc13717
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