Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice

OBJECTIVE: Thrombin has multiple proatherogenic effects including platelet activation and the induction of inflammatory processes. Recently, the cytokine oncostatin M has been shown to have proinflammatory effects. This study was designed to investigate the effects of thrombin inhibition on the init...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Preusch, Michael R, Ieronimakis, Nicholas, Wijelath, Errol S, Cabbage, Sara, Ricks, Jerry, Bea, Florian, Reyes, Morayma, van Ryn, Joanne, Rosenfeld, Michael E
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572747/
https://ncbi.nlm.nih.gov/pubmed/26392754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S86969
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