Volume replacement strategies do not impair the binding of dabigatran to idarucizumab: Porcine model of hemodilution

BACKGROUND: Idarucizumab is a humanized Fab fragment that specifically reverses dabigatran anticoagulation. In trauma, volume expanders are used for resuscitation to compensate for blood loss and hemorrhagic shock, but it is unknown whether volume expanders influence the binding of dabigatran to its...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Grottke, Oliver, van Ryn, Joanne, Zentai, Christian, Gan, Guanfa, Honickel, Markus, Rossaint, Rolf, ten Cate, Hugo, Spronk, Henri M. H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322768/
https://ncbi.nlm.nih.gov/pubmed/30615630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0209350
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