Volume replacement strategies do not impair the binding of dabigatran to idarucizumab: Porcine model of hemodilution

BACKGROUND: Idarucizumab is a humanized Fab fragment that specifically reverses dabigatran anticoagulation. In trauma, volume expanders are used for resuscitation to compensate for blood loss and hemorrhagic shock, but it is unknown whether volume expanders influence the binding of dabigatran to its...

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Foilsithe in:PLoS One
Main Authors: Grottke, Oliver, van Ryn, Joanne, Zentai, Christian, Gan, Guanfa, Honickel, Markus, Rossaint, Rolf, ten Cate, Hugo, Spronk, Henri M. H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2019
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322768/
https://ncbi.nlm.nih.gov/pubmed/30615630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0209350
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