A “Shot in the Arm” for Sickle Cell Disease

av Townes, Tim M.
I publikationen Mol Ther (2021)

Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation

av Chen, Wen Yong, Townes, Tim M.
Publicerad 2000

Broad T-Cell Receptor Repertoire in T-Lymphocytes Derived from Human Induced Pluripotent Stem Cells

av Chang, Chia-Wei, Lai, Yi-Shin, Lamb, Lawrence S., Townes, Tim M.
Publicerad 2014

Negative Regulation of IRF7 Activation by ATF4 Suggests a Cross Regulation Between the Interferon Responses and the Cellular Integrated Stress Responses

av Liang, Qiming, Deng, Hongying, Sun, Chiao-Wang, Townes, Tim M., Zhu, Fanxiu
Publicerad 2010

Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts

av Zhou, Dewang, Ren, Jin-Xiang, Ryan, Thomas M., Higgins, N. Patrick, Townes, Tim M.
Publicerad 2004

Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene

av Divoky, Vladimir, Liu, Zhiyong, Ryan, Thomas M., Prchal, Jaroslav F., Townes, Tim M., Prchal, Josef T.
Publicerad 2001

Trichostatin A Up-Regulates Human Papillomavirus Type 11 Upstream Regulatory Region-E6 Promoter Activity in Undifferentiated Primary Human Keratinocytes

av Zhao, Wei, Noya, Francisco, Chen, Wen Yong, Townes, Tim M., Chow, Louise T., Broker, Thomas R.
Publicerad 1999

Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase

av Chen, Wen Yong, Bailey, Evans C., McCune, Steven L., Dong, Jian-Yun, Townes, Tim M.
Publicerad 1997

Correction of sickle cell disease by homologous recombination in embryonic stem cells

av Wu, Li-Chen, Sun, Chiao-Wang, Ryan, Thomas M., Pawlik, Kevin M., Ren, Jinxiang, Townes, Tim M.
Publicerad 2006

SRY (sex determining region Y)-box2 (Sox2)/poly ADP-ribose polymerase 1 (Parp1) complexes regulate pluripotency

av Lai, Yi-Shin, Chang, Chia-Wei, Pawlik, Kevin M., Zhou, Dewang, Renfrow, Matthew B., Townes, Tim M.
Publicerad 2012

Alterations in Expression and Chromatin Configuration of the Alpha Hemoglobin-Stabilizing Protein Gene in Erythroid Krüppel-Like Factor-Deficient Mice

av Pilon, Andre M., Nilson, Douglas G., Zhou, Dewang, Sangerman, Jose, Townes, Tim M., Bodine, David M., Gallagher, Patrick G.
Publicerad 2006

Sickle Cells Abolish Melanoma Tumorigenesis in Hemoglobin SS Knockin Mice and Augment the Tumoricidal Effect of Oncolytic Virus In Vivo

av Sun, Chiang Wang, Willmon, Candice, Wu, Li-Chen, Knopick, Peter, Thoerner, Jutta, Vile, Richard, Townes, Tim M., Terman, David S.
I publikationen Front Oncol (2016)

Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis

av Suragani, Rajasekhar N. V. S., Zachariah, Roshini S., Velazquez, Jason G., Liu, Sijin, Sun, Chiao-Wang, Townes, Tim M., Chen, Jane-Jane
Publicerad 2012

ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo

av Lange, Philipp S., Chavez, Juan C., Pinto, John T., Coppola, Giovanni, Sun, Chiao-Wang, Townes, Tim M., Geschwind, Daniel H., Ratan, Rajiv R.
Publicerad 2008

Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell–Derived Cells: Universal Donor for Cell Therapy

av Mattapally, Saidulu, Pawlik, Kevin M., Fast, Vladimir G., Zumaquero, Esther, Lund, Frances E., Randall, Troy D., Townes, Tim M., Zhang, Jianyi
I publikationen J Am Heart Assoc (2018)

Exogenous sickle erythrocytes combined with vascular disruption trigger disseminated tumor vaso-occlusion and lung tumor regression

av Sun, Chiao-Wang, Wu, Li-Chen, Wankhede, Mamta, Wang, Dezhi, Thoerner, Jutta, Woody, Lawrence, Sorg, Brian S., Townes, Tim M., Terman, David S.
I publikationen JCI Insight (2019)

Endothelin‐1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species

av Brett Heimlich, J, Speed, Joshua S, O'Connor, Paul M, Pollock, Jennifer S, Townes, Tim M, Meiler, Steffen E, Kutlar, Abdullah, Pollock, David M
I publikationen Br J Pharmacol (2016)

Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation

av Hiratani, Ichiro, Ryba, Tyrone, Itoh, Mari, Yokochi, Tomoki, Schwaiger, Michaela, Chang, Chia-Wei, Lyou, Yung, Townes, Tim M, Schübeler, Dirk, Gilbert, David M
Publicerad 2008

The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis

av Shao, Zhicheng, Zhang, Ruowen, Khodadadi-Jamayran, Alireza, Chen, Bo, Crowley, Michael R., Festok, Muhamad A., Crossman, David K., Townes, Tim M., Hu, Kejin
I publikationen Nat Commun (2016)

Long-Term Endothelin-A Receptor Antagonism Provides Robust Renal Protection in Humanized Sickle Cell Disease Mice

av Kasztan, Malgorzata, Fox, Brandon M., Speed, Joshua S., De Miguel, Carmen, Gohar, Eman Y., Townes, Tim M., Kutlar, Abdullah, Pollock, Jennifer S., Pollock, David M.
I publikationen J Am Soc Nephrol (2017)