Long-Term Endothelin-A Receptor Antagonism Provides Robust Renal Protection in Humanized Sickle Cell Disease Mice

Sickle cell disease (SCD)–associated nephropathy is a major source of morbidity and mortality in patients because of the lack of efficacious treatments targeting renal manifestations of the disease. Here, we describe a long-term treatment strategy with the selective endothelin-A receptor (ET(A)) ant...

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Veröffentlicht in:J Am Soc Nephrol
Hauptverfasser: Kasztan, Malgorzata, Fox, Brandon M., Speed, Joshua S., De Miguel, Carmen, Gohar, Eman Y., Townes, Tim M., Kutlar, Abdullah, Pollock, Jennifer S., Pollock, David M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2017
Schlagworte:
Basic Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533228/
https://ncbi.nlm.nih.gov/pubmed/28348063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016070711
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