Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis

Heme-regulated eIF2α kinase (Hri) is necessary for balanced synthesis of heme and globin. In addition, Hri deficiency exacerbates the phenotypic severity of β-thalassemia intermedia in mice. Activation of Hri during heme deficiency and in β-thalassemia increases eIF2α phosphorylation and inhibits gl...

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Detaylı Bibliyografya
Asıl Yazarlar: Suragani, Rajasekhar N. V. S., Zachariah, Roshini S., Velazquez, Jason G., Liu, Sijin, Sun, Chiao-Wang, Townes, Tim M., Chen, Jane-Jane
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2012
Konular:
Red Cells, Iron, and Erythropoiesis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369616/
https://ncbi.nlm.nih.gov/pubmed/22498744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-388132
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