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The function of heme-regulated eIF2α kinase in murine iron homeostasis and macrophage maturation
Heme-regulated eIF2α kinase (HRI) plays an essential protective role in anemias of iron deficiency, erythroid protoporphyria, and β-thalassemia. In this study, we report that HRI protein is present in murine macrophages, albeit at a lower level than in erythroid precursors. Hri(–/–) mice exhibited i...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2000811/ https://ncbi.nlm.nih.gov/pubmed/17932563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32084 |
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