The function of heme-regulated eIF2α kinase in murine iron homeostasis and macrophage maturation

Heme-regulated eIF2α kinase (HRI) plays an essential protective role in anemias of iron deficiency, erythroid protoporphyria, and β-thalassemia. In this study, we report that HRI protein is present in murine macrophages, albeit at a lower level than in erythroid precursors. Hri(–/–) mice exhibited i...

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Main Authors: Liu, Sijin, Suragani, Rajasekhar N.V.S., Wang, Fudi, Han, Anping, Zhao, Wanting, Andrews, Nancy C., Chen, Jane-Jane
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2007
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000811/
https://ncbi.nlm.nih.gov/pubmed/17932563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32084
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