Haem-regulated eIF2α kinase is necessary for adaptive gene expression in erythroid precursors under the stress of iron deficiency

Haem-regulated eIF2α kinase (HRI) is essential for the regulation of globin gene translation and the survival of erythroid precursors in iron/haem deficiency. This study found that that in iron deficiency, fetal definitive erythropoiesis is inhibited at the basophilic erythroblast stage with increas...

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Detalhes bibliográficos
Publicado no:Br J Haematol
Main Authors: Liu, Sijin, Bhattacharya, Sanchita, Han, Anping, Suragani, Rajasekhar N. V. S., Zhao, Wanting, Fry, Rebecca C., Chen, Jane-Jane
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072281/
https://ncbi.nlm.nih.gov/pubmed/18665838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2008.07293.x
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