Heme-regulated eIF2α kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency

Although the physiological role of tissue-specific translational control of gene expression in mammals has long been suspected on the basis of biochemical studies, direct evidence has been lacking. Here, we report on the targeted disruption of the gene encoding the heme-regulated eIF2α kinase (HRI)...

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Main Authors: Han, An-Ping, Yu, Channing, Lu, Linrong, Fujiwara, Yuko, Browne, Carol, Chin, Gregory, Fleming, Mark, Leboulch, Philippe, Orkin, Stuart H., Chen, Jane-Jane
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2001
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC125753/
https://ncbi.nlm.nih.gov/pubmed/11726526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.23.6909
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