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Deficiency of heme-regulated eIF2α kinase decreases hepcidin expression and splenic iron in HFE(−/−) mice
Heme-regulated eIF2α kinase (HRI) is essential for regulating globin translation in iron deficiency and in β-thalassemia. We investigated the role of heme-regulated eIF2α kinase in hemoglobin and red blood cell production as well as in iron homeostasis in a mouse model of iron overload. We show that...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3621076/ https://ncbi.nlm.nih.gov/pubmed/18367482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.12175 |
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