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Deficiency of heme-regulated eIF2α kinase decreases hepcidin expression and splenic iron in HFE(−/−) mice

Heme-regulated eIF2α kinase (HRI) is essential for regulating globin translation in iron deficiency and in β-thalassemia. We investigated the role of heme-regulated eIF2α kinase in hemoglobin and red blood cell production as well as in iron homeostasis in a mouse model of iron overload. We show that...

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Bibliografiske detaljer
Main Authors: Liu, Sijin, Suragani, Rajasekhar N.V.S., Han, Anping, Zhao, Wanting, Andrews, Nancy C., Chen, Jane-Jane
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3621076/
https://ncbi.nlm.nih.gov/pubmed/18367482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.12175
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