Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation

DNA replication in mammals is regulated via the coordinate firing of clusters of replicons that duplicate megabase-sized chromosome segments at specific times during S-phase. Cytogenetic studies show that these “replicon clusters” coalesce as subchromosomal units that persist through multiple cell g...

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Main Authors: Hiratani, Ichiro, Ryba, Tyrone, Itoh, Mari, Yokochi, Tomoki, Schwaiger, Michaela, Chang, Chia-Wei, Lyou, Yung, Townes, Tim M, Schübeler, Dirk, Gilbert, David M
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2008
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561079/
https://ncbi.nlm.nih.gov/pubmed/18842067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0060245
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