Impact of heat-shock protein 90 on cancer metastasis

Por Tsutsumi, Shinji, Beebe, Kristin, Neckers, Len
Publicado em 2009

Targeting Hsp90 prevents escape of breast cancer cells from tyrosine kinase inhibition

Por Pashtan, Itai, Tsutsumi, Shinji, Wang, Suiquan, Xu, Wanping, Neckers, Len
Publicado em 2008

Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity

Por Mollapour, Mehdi, Tsutsumi, Shinji, Kim, Yeong Sang, Trepel, Jane, Neckers, Len
Publicado em 2011

Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone

Por Yano, Akihiro, Tsutsumi, Shinji, Soga, Shiro, Lee, Min-Jung, Trepel, Jane, Osada, Hiroyuki, Neckers, Len
Publicado em 2008

Divergent Synthesis of a Pochonin Library Targeting HSP90 and in vivo Efficacy of Identified Inhibitor

Por Barluenga, Sofia, Wong, Cuihua, Fontaine, Jean-Gonzague, Aouadi, Kaïss, Beebe, Kristin, Tsutsumi, Shinji, Neckers, Len, Winssinger, Nicolas
Publicado em 2008

Perioperative Blood Transfusion as a Poor Prognostic Factor After Aggressive Surgical Resection for Hilar Cholangiocarcinoma

Por Kimura, Norihisa, Toyoki, Yoshikazu, Ishido, Keinosuke, Kudo, Daisuke, Yakoshi, Yuta, Tsutsumi, Shinji, Miura, Takuya, Wakiya, Taiichi, Hakamada, Kenichi
Publicado no J Gastrointest Surg (2015)

Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity

Por Tsutsumi, Shinji, Mollapour, Mehdi, Prodromou, Chrisostomos, Lee, Chung-Tien, Panaretou, Barry, Yoshida, Soichiro, Mayer, Matthias P., Neckers, Leonard M.
Publicado em 2012

Streptococcal Toxic Shock Syndrome: Life Saving Role of Peritoneal Lavage and Drainage

Por Yokoyama, Minako, Oyama, Fumie, Ito, Asami, Yokota, Megumi, Matsukura, Daisuke, Tsutsumi, Shinji, Kasai, Tomonori, Nitobe, Yohshiro, Morikawa, Akiko, Ozaki, Takashi, Yokoyama, Yoshihito
Publicado no Clin Med Insights Case Rep (2016)

An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function

Por Scroggins, Bradley T., Robzyk, Kenneth, Wang, Dongxia, Marcu, Monica G., Tsutsumi, Shinji, Beebe, Kristin, Cotter, Robert J., Felts, Sara, Toft, David, Karnitz, Larry, Rosen, Neal, Neckers, Len
Publicado em 2007

Effects of S-1 as a second-line chemotherapy for patients with relapsed pancreatic cancer

Por ISHIDO, KEINOSUKE, TOYOKI, YOSHIKAZU, KUDO, DAISUKE, KIMURA, NORIHISA, YAMANA, DAISUKE, MIURA, TAKUYA, TSUTSUMI, SHINJI, MUROYA, TAKAHIRO, YOSHIKAWA, TORU, OGASAWARA, HIROSHI, YONAIYAMA, SHINNOSUKE, NARUMI, SHUNJI, HAKAMADA, KENICHI
Publicado em 2011

Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants

Por Prince, Thomas L., Kijima, Toshiki, Tatokoro, Manabu, Lee, Sunmin, Tsutsumi, Shinji, Yim, Kendrick, Rivas, Candy, Alarcon, Sylvia, Schwartz, Harvey, Khamit-Kush, Kofi, Scroggins, Bradley T., Beebe, Kristin, Trepel, Jane B., Neckers, Len
Publicado no PLoS One (2015)

Threonine 22 phosphorylation attenuates Hsp90 interaction with co-chaperones and affects its chaperone activity

Por Mollapour, Mehdi, Tsutsumi, Shinji, Truman, Andrew W., Xu, Wanping, Vaughan, Cara K., Beebe, Kristin, Konstantinova, Anna, Vourganti, Srinivas, Panaretou, Barry, Piper, Peter W., Trepel, Jane B., Prodromou, Chrisostomos, Pearl, Laurence H., Neckers, Len
Publicado em 2011

Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells

Por Iwai, Aki, Bourboulia, Dimitra, Mollapour, Mehdi, Jensen-Taubman, Sandra, Lee, Sunmin, Donnelly, Alison C., Yoshida, Soichiro, Miyajima, Naoto, Tsutsumi, Shinji, Smith, Armine K., Sun, David, Wu, Xiaolin, Blagg, Brian S., Trepel, Jane B., Stetler-Stevenson, William G., Neckers, Len
Publicado em 2012

Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

Por Yoshida, Soichiro, Tsutsumi, Shinji, Muhlebach, Guillaume, Sourbier, Carole, Lee, Min-Jung, Lee, Sunmin, Vartholomaiou, Evangelia, Tatokoro, Manabu, Beebe, Kristin, Miyajima, Naoto, Mohney, Robert P., Chen, Yang, Hasumi, Hisashi, Xu, Wanping, Fukushima, Hiroshi, Nakamura, Ken, Koga, Fumitaka, Kihara, Kazunori, Trepel, Jane, Picard, Didier, Neckers, Leonard
Publicado em 2013

Swe1(Wee1)-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function

Por Mollapour, Mehdi, Tsutsumi, Shinji, Donnelly, Alison C., Beebe, Kristin, Tokita, Mari J., Lee, Min-Jung, Lee, Sunmin, Morra, Giulia, Bourboulia, Dimitra, Scroggins, Bradley T., Colombo, Giorgio, Blagg, Brian S., Panaretou, Barry, Stetler-Stevenson, William G., Trepel, Jane B., Piper, Peter W., Prodromou, Chrisostomos, Pearl, Laurence H., Neckers, Len
Publicado em 2010

Asymmetric Hsp90 N-domain SUMOylation recruits Aha1 and ATP-competitive inhibitors

Por Mollapour, Mehdi, Bourboulia, Dimitra, Beebe, Kristin, Woodford, Mark R., Polier, Sigrun, Hoang, Anthony, Chelluri, Raju, Li, Yu, Guo, Ailan, Lee, Min-Jung, Fotooh-Abadi, Elham, Khan, Sahar, Prince, Thomas, Miyajima, Naoto, Yoshida, Soichiro, Tsutsumi, Shinji, Xu, Wanping, Panaretou, Barry, Stetler-Stevenson, William G., Bratslavsky, Gennady, Trepel, Jane B., Prodromou, Chrisostomos, Neckers, Len
Publicado em 2014

Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors

Por Woodford, Mark R., Truman, Andrew W., Dunn, Diana M., Jensen, Sandra M., Cotran, Richard, Bullard, Renee, Abouelleil, Mourad, Beebe, Kristin, Wolfgeher, Donald, Wierzbicki, Sara, Post, Dawn E., Caza, Tiffany, Tsutsumi, Shinji, Panaretou, Barry, Kron, Stephen J., Trepel, Jane B., Landas, Steve, Prodromou, Chrisostomos, Shapiro, Oleg, Stetler-Stevenson, William G., Bourboulia, Dimitra, Neckers, Len, Bratslavsky, Gennady, Mollapour, Mehdi
Publicado no Cell Rep (2016)