Gambogic acid identifies an isoform-specific druggable pocket in the middle domain of Hsp90β

Por Yim, Kendrick H., Prince, Thomas L., Qu, Shiwei, Bai, Fang, Jennings, Patricia A., Onuchic, José N., Theodorakis, Emmanuel A., Neckers, Leonard
Publicado no Proc Natl Acad Sci U S A (2016)

Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants

Por Prince, Thomas L., Kijima, Toshiki, Tatokoro, Manabu, Lee, Sunmin, Tsutsumi, Shinji, Yim, Kendrick, Rivas, Candy, Alarcon, Sylvia, Schwartz, Harvey, Khamit-Kush, Kofi, Scroggins, Bradley T., Beebe, Kristin, Trepel, Jane B., Neckers, Len
Publicado no PLoS One (2015)