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Gambogic acid identifies an isoform-specific druggable pocket in the middle domain of Hsp90β
Because of their importance in maintaining protein homeostasis, molecular chaperones, including heat-shock protein 90 (Hsp90), represent attractive drug targets. Although a number of Hsp90 inhibitors are in preclinical/clinical development, none strongly differentiate between constitutively expresse...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4995996/ https://ncbi.nlm.nih.gov/pubmed/27466407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606655113 |
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