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Gambogic Acid, a Natural Product Inhibitor of Hsp90

A high-throughput screening of natural product libraries identified (−)-gambogic acid (1), a component of the exudate of Garcinia harburyi, as a potential Hsp90 inhibitor, in addition to the known Hsp90 inhibitor celastrol (2). Subsequent testing established that 1 inhibited cell proliferation, brou...

詳細記述

保存先:
書誌詳細
主要な著者: Davenport, Jason, Manjarrez, Jacob R., Peterson, Laura, Krumm, Brian, Blagg, Brian S. J., Matts, Robert L.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103600/
https://ncbi.nlm.nih.gov/pubmed/21486005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np200029q
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