Elucidation of the Hsp90 C-terminal Inhibitor Binding Site

The Hsp90 chaperone machine is required for the folding, activation and/or stabilization of more than 50 proteins directly related to malignant progression. Hsp90 contains small molecule binding sites at both its N- and C-terminal domains, however, limited structural and biochemical data regarding t...

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Bibliografske podrobnosti
Main Authors: Matts, Robert L., Dixit, Anshuman, Peterson, Laura B., Sun, Liang, Voruganti, Sudhakar, Kalyanaraman, Palgunan, Hartson, Steve D., Verkhivker, Gennady M., Blagg, Brian S. J.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164513/
https://ncbi.nlm.nih.gov/pubmed/21548602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200052x
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