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Elucidation of the Hsp90 C-terminal Inhibitor Binding Site
The Hsp90 chaperone machine is required for the folding, activation and/or stabilization of more than 50 proteins directly related to malignant progression. Hsp90 contains small molecule binding sites at both its N- and C-terminal domains, however, limited structural and biochemical data regarding t...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3164513/ https://ncbi.nlm.nih.gov/pubmed/21548602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200052x |
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